The synthesis of 2-amino-2-deoxyhexoses: D-glucosamine, D-mannosamine, D-galactosamine, and D-talosamine
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D-Galactosamine and D-mannosamine also reduced the via biity and transplantability of ascites tumor cells similar to that of D-glucosamine. However, the N-acetylhexosamines
D-Glucosamine has been shown to have a powerful cytotoxic effect on various ascites tumor lines, resulting in a decrease in viability and transplantability of the neoplastic cells. The toxic effect of glucosamine was not significantly altered by addition of either glucose or pyruvate. The effects of D-glucosamine and other sugar analogs were evident histologically even before the cells became s...
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Intraperitoneal (IP) injection of bupropion (3,6, amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-ad...
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As repor ted earlier 1, an e n z y m e purif ied f rom Clostridium per#ingens (N-ace ty lneuramin ic acid aldolase; NaNaldolase) ca ta lyzes t he following reversible reac t ion: p y r u v a t e + N-acetyl-Dm a n n o s a m i n e (N-AcMm) ~ N-ace t y l neu rami n i c acid (sialic acid). The recogni t ion of N A c M m as a na tu ra l l y occurr ing suga r leads to t h e ques t ion of t he m e c h...
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The specificity of the reaction for amino sugars discovered by Elson & Morgan (1933) has been increased by several workers through knowledge of some of the intermediates involved. The interference by amino acids and glucose was overcome in different ways (Schloss, 1951; Immers & Vasseur, 1952; Cessi, 1952; Cessi & Piliego, 1960). The separation of a volatile fraction among the products of conde...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1968
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v68-064